Document Details

Document Type : Article In Journal 
Document Title :
synthesis and NOE AND 2D- NOESY spectroscopic studies of two n- propionyl derivatives of terpene-derived chiral auxilaries
والتوليف وNOE 2D-NOESY الدراسات الطيفية للمشتقات N-بروبيونيل اثنين من المساعدين تيربين المستمدة مراوان
 
Subject : synthesis and NOE AND 2D- NOESY spectroscopic studies of two n- propionyl derivatives of terpene-derived chiral auxilaries 
Document Language : English 
Abstract : The synthesis of two N-propionyl derivatives of terpene-derived chiral auxiliaries (one is derived from (-)-3-pinanol, and the other from isomenthol) has been achieved via the use of n-butyllithium as a base and propionyl chloride as an acylation reagent. In order to increase the yield of both N-propionyl derivatives, particularly N-propionyl derivative of chiral auxiliary derived from isomenthol, the alternative acylation reagent was employed for this purpose. Using, cheap and readily available acylation reagent, propionic anhydride gave almost the same yield of N-propionyl derivative of chiral auxiliary derived from (-)-3-pinanol, but unfortunately, this procedure did not increase the yield of the N-propionyl derivative of chiral auxiliary derived from isomenthol much, although it was slightly better. Attempts to distinguish between the prochiral methylene protons in the N-propionyl group, and all other diastereotopic protons and methyl groups in these two N-propionyl derivatives of chiral auxiliaries were carried out by using 1H NMR nOe difference spectra and 2D-NOESY spectroscopic studies. 
ISSN : 1319-6103 
Journal Name : Journal of Saudi Chemical Society 
Volume : 4 
Issue Number : 3 
Publishing Year : 1420 AH
2000 AD 
Article Type : Article 
Added Date : Sunday, March 24, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
صالح طارق جمالJamal, Saleh TariqResearcherDoctorate 

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