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Document Type |
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Article In Journal |
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Document Title |
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granulomatous mastitis التهاب الضرع |
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Subject |
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granulomatous mastitis |
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Document Language |
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Arabic |
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Abstract |
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Patients mostly present with a hard lump in one breast without any sign of a systemic disease. Other possible symptoms include nipple retraction, pain, inflammation of the overlying sking, nipple discharge, fistula, enlarged lymph nodes, in rare case peau d'orange-like changes.
Presentation is mostly unilateral although a significant share of cases is bilateral, also in many cases contralateral or bilateral recurrences were documented.
Several cases occurring together with fever, polyarthralgia and erythema nodosum were documented.
Characteristic for idiopathic granulomatous mastitis are multinucleated giant cells and epithelioid histiocytes forming non-caseating granulomas around lobules. Often minor ductal and periductal inflammation is present. The lesion is in some cases very difficult to distinguish from breast cancer and other causes such as infections (tuberculosis, syphilis, corynebacterial infection, mycotic infection), autoimmune diseases (sarcoidosis, Wegener's granulomatosis), foreign body reaction and granulomatous reaction in a carcinoma must be excluded.[1] [5]
The condition is diagnosed very rarely. As the diagnosis is a lengthy differential diagnosis of exclusion there is considerable uncertainty about incidence. It has been suspected that some cases diagnosed as IGM in developing countries may have other explanations. On the other hand IGM is usually diagnosed only after complications and referral to a secondary breast care center so light cases may resolve spontaneously or after symptomatic treatment and thus never be diagnosed as IGM. As a completely pathogen free breast will be exceedingly rare even in completely healthy population there is also uncertainty when to consider pathogens as causative or as mere coincidental finding.
[edit] Causes |
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ISSN |
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0250-6882 |
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Journal Name |
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emirates medical journal |
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Volume |
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18 |
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Issue Number |
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2 |
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Publishing Year |
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1420 AH
2000 AD |
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Article Type |
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Article |
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Added Date |
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Wednesday, March 13, 2013 |
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Researchers
| محمد احمد الحربي | alharbi, mohamed ahmad | Researcher | Doctorate | |
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