Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Haemostatic Variation in Male Smokers with Rheumatoid Arthritis التغيير في عوامل النزف في الذكور المدخنين المصابين بالتهاب المفاصل |
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Subject |
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Haemostatic Variation in Male Smokers with Rheumatoid Arthritis |
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Document Language |
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English |
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Abstract |
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The present work aims to assess the impact of cigarette smoking on haemostatic equilibria versus the magnitude of vascular endothelial damage in male subjects with and without rheumatoid arthritis.
For this purpose, thirty male smokers (age range 30-45 years) were classified into two equal groups (GI and Gil). Cases in Gil were with rheumatoid arthritis and cases in Gil were without rheumatoid arthritis. Thirty age-matched non-smokers were similarly classified into cases with rheumatoid arthritis (Gill) and healthy normal controls (GIV). Biochemical assessments involved: serum cotinine levels, percent of total antioxidant capacity (AOC%); Glutathione peroxidase (GSH-Px) enzyme activity; indices of vascular endothelial damage [fibronectin (FN) and E-selectionj, and interleukin- 1 3 (IL-13); Trace elements (copper, zinc, and selenium); indices of inflammation [ceruloplasirnin (CP), C reactive protein (CRP), and sialic acidj; and indices of homeostatic equilibria {lipoprotein (a) [Lp(a)J, antithrombin III (AT III), tissue plasminogen activator (tP A), and plasminogen activator inhibito- 1 (PM- i)}.
The results showed significant variations in serum cotinine levels in smokers coordinated with increased levels of FN, E-selectin, IL- I 3, copper, Cp, CRP, sialic acid , Lp (a) and PAl-i versus decreased ACO%, GSH-Px, zinc, selenium, AT III and t-PA. Greater magnitude of change in assessed data was potentiated by the dual impact of smoking and rheumatoid arthritis.
With respect to the abovementioned findings, it could be concluded that a synergistic interaction occurred between products of cigarette smoke inhaled and mediators of inflammatory response to rheumatoid arthritis. Their impact on magnitude of oxidative stress-induced vascular endothelial damage was equivocal to variation in induced of haernostatic equilibria. |
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ISSN |
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1687-1502 |
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Journal Name |
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Egyptian Journal of Biochemistry and Molecular Biology |
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Volume |
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19 |
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Issue Number |
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2 |
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Publishing Year |
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1422 AH
2001 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, February 17, 2013 |
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Researchers
| خالد عمر ابو النجا | abualnaja, khaleed omer | Researcher | Doctorate | kabualnaja@kau.edu.sa |
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