Document Details

Document Type : Article In Journal 
Document Title :
Growth hormone for children with chronic renal failure and on dialysis
هرمون النّموّ للأطفال بفشل كلويّ مزمن و على غسيل الكلية
 
Subject : Growth hormone for children with chronic renal failure and on dialysis 
Document Language : English 
Abstract : We studied all children with CRF who received recombinant human growth hormone (rhGH) for more than a year (mean±SD duration of therapy 3.7±2.5 years) over an 11-year period. There were 32 children. Twenty-one children were conservatively managed, with a mean glomerular filtration rate (GFR) of 24±12 mL min–1/1.73 m2 at the start of rhGH. Their height standard deviation score improved from –2.5±1.4 to –2.1±0.7 at 1 year (P=0.3), –2.0±0.7 at 2 years (P=0.01), and –1.6±0.6 at 3 years (P=0.001). After that there was no improvement. Eleven children were on dialysis, six on haemodialysis (HD) and five on peritoneal (PD). Ht SDS improved from –2.7±0.5 to –2.3±0.5 at 1 year (P=0.02). Thereafter there was no further improvement. RhGH was stopped because of transplantation in 29 patients at a mean±SD age of 12.1±4.0 years. Mean Ht SDS was –1.8±0.8 at transplant and there was no change over the following 5 years. In conclusion, treatment with rhGH resulted in improvement in Ht SDS in conservatively managed CRF for up to 3.0 years and for 1 year in children on dialysis. Discontinuation of rhGH after transplantation resulted in little change in Ht SDS. 
ISSN : 1319-1004 
Journal Name : Medical Science Journal 
Volume : 20 
Issue Number : 5 
Publishing Year : 1424 AH
2005 AD 
Article Type : Article 
Added Date : Sunday, February 6, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
جميلة قاريkari, jameela ResearcherDoctorate 

Files

File NameTypeDescription
 28883.pdf pdf 

Back To Researches Page